GHK-CU

About GHK-CU

GHK-Cu is the copper(II) coordination complex of the tripeptide glycyl-L-histidyl-L-lysine, a naturally occurring copper-binding sequence whose plasma concentrations have been reported to decline with age. The copper ion is chelated by the peptide in a defined planar geometry, and this metal-peptide coordination is central to its biological activity. Researchers study GHK-Cu in models of dermal and connective-tissue remodeling, collagen and glycosaminoglycan synthesis, angiogenesis-related signaling, and gene-expression changes associated with wound repair. Its applications also extend to copper-homeostasis research, since the complex delivers copper in a controlled manner compared with free copper salts. Quality control must address both peptide purity and stoichiometric metal content: excess free copper, incomplete complexation, or decomposition during lyophilization can change cellular responses. Shandong Shengyuan supplies GHK-Cu at 99.5% peptide purity by RP-HPLC or higher, with copper content confirmed analytically and LC-MS verification of the peptide backbone. Lyophilized product is for research use only; not for human or veterinary use.

Research Applications

• Dermal remodeling research
• Collagen synthesis assays
• Copper homeostasis studies
• Angiogenesis models
• Wound repair biology

Quality & Documentation

Every batch of GHK-CU is manufactured under our documented quality system and released with a Certificate of Analysis covering HPLC purity, mass spectrometry identity, peptide content, water content, and endotoxin. The batch code on your vial can be verified online in the COA lookup section of this site.